2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Med J Aust; 193(9):525-32. Applies only to oral form of both agents. Minor/Significance Unknown. Minor/Significance Unknown. Venofer Injection Prescribing Information - Drugs.com May increase risk of hypotension. DailyMed - VENOFER- IRON SUCROSE injection, solution 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Applies only to oral form of both agents. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Iron sucrose | Drugs | BNF | NICE Medically reviewed by Drugs.com. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Where: Medicine concentration Amount of active substance per a given volume of your drug. We comply with the HONcode standard for trustworthy health information. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Applies only to oral form of both agents. Assessing new treatment options. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. 1998 Feb;25(1):65-8. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Human studies not conducted. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Although the original formula requires the weight in kilograms, values input in lbs are transformed. No data are available regarding overdosage of Venofer in humans. Included in the iron dextran package insert. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Intravenous iron sucrose: establishing a safe dose - PubMed Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Use Caution/Monitor. All Rights Reserved. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Deferoxamine chelates iron. These can be input in g/dL, g/L or mmol/L. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. If we don't have the calculator you need then tell us the details and we'll make it for you. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Schrier SL, Mentzer WC, Landaw SA. Monofer 100mg/ml solution for injection/infusion - Summary of Product Baloxavir may bind to polyvalent cations resulting in decreased absorption. Avoid or Use Alternate Drug. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. By using this form you agree with the storage and handling of your data by this website. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Injection site discoloration has been reported following extravasation. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. 2.1 . Applies only to oral form of both agents. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. This site complies with the HONcode standard for trust- worthy health information: verify here. iron sucrose increases levels of calcium acetate by enhancing GI absorption. David McAuley, Pharm.D. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Use Caution/Monitor. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. PDF Treatment Guideline - Gloucestershire Royal Hospital Comparable efficacy to that of IV iron sucrose. Applies only to oral form of both agents. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Applies only to oral form of both agents. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration The above information is provided for general Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Use Caution/Monitor. Read our. Avoid or Use Alternate Drug. Applies only to oral form of both agents. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Parenteral iron supplementation. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Applies only to oral form of both agents. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Dosing and Infusion Rates - PRIVIGEN Modify Therapy/Monitor Closely. Your doctor will do laboratory tests to monitor your response. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. This website also contains material copyrighted by 3rd parties. Slowing the infusion rate may alleviate symptoms. Intravenous iron therapy for patients with anemia iron sucrose decreases levels of manganese by inhibition of GI absorption. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. J Lab Clin Med; 111(5):566-70. Use Caution/Monitor. STORAGE: Consult the product instructions and your pharmacist for storage details. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. The iron formulation choice remains for the clinician to make. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Perinatology and Obstetrical Calculators Avoid or Use Alternate Drug. Applies only to oral form of both agents. Applies only to oral form of both agents. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. iron sucrose, benazepril. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Monitor for signs and symptoms of hypotension following each Feraheme infusion. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. Avoid or Use Alternate Drug. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Applies only to oral form of both agents. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList There is in depth information below the form on the method used and on the result provided. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Separate by at least 4 hours. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Iron Deficiency in Heart Failure - Home - American College of Cardiology PDF Venofer - Food and Drug Administration Schweiz Med Wochenschr; 100(7):301-3. Iron Sucrose Protocol - Cmqcc The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Interaction only with oral iron administration. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Use Caution/Monitor. This topic . Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. 1. Applies only to oral form of both agents. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Venofer is given as an infusion into a vein. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Minor/Significance Unknown. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Venofer treatment may be repeated if necessary. Use Caution/Monitor. Total dose iron infusion: safety and efficacy in predialysis patients. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Share cases and questions with Physicians on Medscape consult. Applies only to oral form of both agents. and formulary information changes. Calculation of Iron Deficit - Perinatology.com ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Objective. Kumpf VJ. Minor/Significance Unknown. elemental iron (mg/ml) in the product being used: Where C= Use Caution/Monitor. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. ANNA J. Avoid or Use Alternate Drug. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition.