steve kirsch fluvoxamine steve kirsch fluvoxamine

His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. It cant be more clear than this. Waiting months for the phase 3 trial to complete is nuts. The medical community did nothing (with a few exceptions like Dr. Seftel). One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). Over the summer, the conflict reached his most recent startup, M10. skirsch.io. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Discover special offers, top stories, Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). We should not wait for the Phase 3 RCT. YouTube , , , fluvoxamine, , , , , , , , , , How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. Their willingness to lie did. Why fluvoxamine isnt used. In-patient use. The effect size is huge if the drug is given early right after symptoms start. . Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. Proxalutamide and fluvoxamine pushers and the early treatment grift. Quick Summary . He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. My favorite dosage is 50mg twice a day for 14 days. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. Im not going to make the same mistake again.. Compulsive fiddling with your mask? The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. It does not matter how many lives will be saved. @stkirsch. The next major effect is that that fluvoxamine activates the sigma-1 receptor. I mean, he really, truly has a heart of gold, Char told me. 90,000 people don't have to die in the next 3 weeks. See my article on treatments. Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. You cannot get any better than that. The sooner you start, the better the outcomes. Hes now outlived his initial prognosis by several years. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. With cases spiking, the Los Angeles area banned gatherings. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. If you take fluvoxamine, please avoid caffeine while on the drug. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. The web price charge of skirsch.io . Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. Thanks for working tirelessly to help others. The NIH never did a risk benefit analysis of this drug. Although the average effect size is 100% with a p-value of <.0001, The Fisher exact test on the combined data suggests that there is a 95% chance that the effect size is at least a 75% reduction in hospitalization rate. . Has it really been 25 years, a whole quarter of a century? The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. You will be wired for 24 hours if you dont heed my advice. By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. skirsch.io Steve Kirsch Home page. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. Fluvoxamine has a 40 year safety track record. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. That is when the phase 2 results were published. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. Food/drugs to avoid while on fluvoxamine. That covers almost 150,000 of them, which happened before vaccinations began. Doing something is better than nothing. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. He may not be a good scientist, but hes smart, says WVUs Feinberg. Medicine today isnt about saving your life. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. The anecdotal data of 100% success rates is further icing on the cake. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Read More fluvoxamine The Fluvoxamine FAQ Every year, we pick the 10 technologies that matter the most right now. Its whether Merck can make a killing that matters. You can use fluoxetine as well (aka Prozac). The incident, he added, was completely in keeping with his personality.. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. So you can address your OCD and if you get COVID, youll can up the dose. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. I believe they made the right decision and we should be rushing to follow their advice. It is very important to educate doctors because most people rely on their doctors for advice. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. See this Wall Street Journal op-ed. Another is to identify an asteroid that is going to hit the planet.. It used to be that a Phase 3 study would do it. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. saying that the per-protocol analysis was arbitrary and other excuses. . There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? . There are 4 outpatient studies that have been done (2 at WashU (see. are all super cheap, effective, and available without a prescription. They rejected the drug for insufficient evidence just like they always do for ivermectin. I fully expected both organizations to do absolutely nothing. Don't underestimate the virus. Silence from the medical community. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. It does not matter how many lives will be saved. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) Some people report mild nausea while on the drug (stops when stop the drug). Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. My crime? Where did it go wrong. 4000fluvoxamine750 There is no evidence fluvoxamine is harmful and led to a worse outcome. Try refreshing this page and updating them one He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. So why would we wait when lives are being lost? Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Their willingness to lie did. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. No long haul symptoms if you start the drug ASAP after first symptoms. The NIH wrote a bullshit rejection because the FDA told them not to approve it. including the very promising Fluvoxamine. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. The FDA approved Molnupiravir which was less effective. Fluvoxamine, COVID, pandemic, . It doesnt get any better than this. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. P-value was 10^-14 on that study (done by Dr. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). Last Checked: 03/02/2023. The. . It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. Some speaker, off camera, went on a . Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. My website www.skirsch.io has tons of info on fluvoxamine with all the links. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). I fully expected both organizations to do absolutely nothing. We are ignoring the advice of the KOL group and doing nothing. Its sad, but its true, he told me. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. It works best when it is given early, as soon as symptoms start. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. Dr. Eric Lenze: So the results were really pretty. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. Lack of action. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. My experience is very typical. Saving the world has been a theme of Kirschs life for years. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. The medical community doesnt care about saving lives. The race to find covid-19 drug treatments that actually work, The antimalarial drug Trump took for covid might actually be dangerous. This is the gold standard of evidence based medicine. He has a history of giving away some of his millions to good causes, and when COVID-19 began. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. I have all of these on hand and I load up on vitamin D3 every day. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Dosage there is 30mg once a day. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. Personal life. Everyone is stunned, but nobody is surprised. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). P-value was 10^-14 on that study (done by Dr. Seftel). In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Or just depression about the vaccine mandates? People are dying. Steve angrily decried this development as more evidence of FDA corruption. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. They never make things worse so are safe to try. I have never heard of a case it didn't work. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . Share this post. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults.